Figure 1

Lengths of the cytoplasmic tails of various retroviruses and sequence alignment of different HIV-1 subtypes, clades and types. (A) Comparison of the lengths of the gp41-CT of Human Immunodeficiency Virus type 1 (HIV-1), HIV type 2 (HIV-2), Simian Immunodeficiency Virus (SIV), Feline Immunodeficiency Virus (FIV), Equine Infectious Anemia Virus (EIAV), Maedi-Visna Virus (MVV), Caprine Arthritis Encephalitis Virus (CAEV), Human T-lymphotropic Virus type I (HTLV-1), Human T-lymphotropic Vtype 2 (HTLV-2), Mouse Mammary Tumor Virus (MMTV), Murine Leukemia Virus (MLV) and Gibbon Ape Leukemia Virus (GaLV); conserved YxxФ motifs (where Ф represents a hydrophobic residue) are highlighted. (B) Sequence alignment of the gp41-CT from various lenviviral (HIV and SIV) types and subtypes: HIV-1 subtypes A (92UG037), B (HXB2), C (ETH2220), D (SE365), F1 (93BR020), G (175), H (90CF056), CRF02_AG (93TH065), clade O (ANT70) and clade N (YBF106), HIV-2 (UC2), SIVcpz (Ptt_04CAM155) and SIVsmm (H635). AA positions are aligned against the NL-3 reference used in most studies of the gp41-CT. Lentiviral lytic peptide (LLP) domains, Kennedy epitopes and antibodies directed against them are shown. Conserved YxxФ motifs are highlighted in orange; conserved dileucine motifs, and motifs involved in cell trafficking are highlighted in green.