Obituary: Kuan-Teh Jeang

Teh (Figure 1) was born in 1958 in Taichung, Taiwan and was the youngest to his two older brothers. Teh spent his childhood in Libya and came to the US in 1970. At age 16, he began college at the Massachusetts Institute of Technology, and after two years, started medical school at Johns Hopkins University, receiving both his M.D. and Ph.D. degrees by age 25. His Ph.D. thesis was on the regulation of gene expression in cytomegalovirus with Dr. Gary S. Hayward as advisor. During his time at Hopkins, Teh met his wife, Diane, a graduate student in the same laboratory. They married in 1984 in Iowa, where Teh completed his medical internship. The next year, Teh started his post-doctoral work at the National Institutes of Health (NIH) in the laboratory of Dr. George Khoury at the National Cancer Institute. Dr. Khoury died much too early at the age of 43 in 1987, but he was Teh’s role model and influenced him greatly in his professional life. As a recognition of his scientific achievements, Teh was recently selected to deliver the 2012 George Khoury Lecture at NIH on cellular transformation by the human T cell leukemia virus (HTLV-I).

Dr Kuan-Teh Jeang.

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Teh had been working at the NIH in Bethesda for 27 years, exactly half of his life, and was chief of the Molecular Virology Section in the Laboratory of Molecular Microbiology. His major research interest was around the human immunodeficiency virus (HIV-1) and HTLV-I, with an abundant production of more than 300 scientific publications on the molecular details of virus replication and relevant disease-causing mechanisms of viral pathogenesis. Teh was a true experimentalist with an interest in the implementation of new technologies to get to the next level of understanding of the biology of human pathogenic viruses. He only stopped bench work in 2004 when he became editor-in-chief of Retrovirology.

HTLV-1 is linked to the development of adult T-cell leukemia and a variety of inflammatory manifestations including HTLV-1 associated myelopathy. Teh was the first to show that HTLV-1 transcription is regulated through the cAMP signaling pathway implicating roles for CREB and CBP before these proteins were clearly identified and cloned. His research team also contributed to our understanding of how the viral Tax oncoprotein activates the pro-inflammatory factor NF-kB. More recently, he proposed a role for deubiquitinases in the regulation of TRAF6–mediated NF-kB signaling. Teh’s work has also advanced our understanding of genetic damage in virus-cellular transformation. In 1990, he first reported that the HTLV-1 Tax oncoprotein repressed DNA-repair. Thereafter, he characterized the important roles of dysregulated mitotic checkpoint and AKT activation in cellular transformation. His work has contributed to the elucidation of the role played by the spindle assembly checkpoint in oncogenesis, helping to explain how the loss of multiple checkpoints alters cancer tropism in vivo.

Teh had a long standing interest in understanding the viral and cellular factors that govern HIV-1 gene expression in infected human cells. In the late 1980s, Teh’s lab showed that HIV-1 uses an unprecedented mechanism of transcription that is dictated by an RNA-binding protein, Tat, which binds a nascent viral RNA target (TAR), the first RNA enhancer element ever described. Subsequently, Teh’s group characterized cellular RNA-binding proteins that regulate HIV-1 replication, including the TAR RNA binding protein (TRBP) that later became known as an important factor of the cellular RNA interference machinery. In recent work, his lab completed a genome-wide screening for human cell factors that are needed for HIV-1 replication. Using novel technology, Teh extended his interests in RNA-biology through the identification of small RNAs (i.e. siRNAs and miRNAs) that have biologically important roles in viral infection, cellular metabolism and virus-induced pathogenesis.

In addition to all these accomplishments, one of Teh’s greatest contributions to science probably lies in his role as mentor for young scientists. Teh trained 37 international postdoctoral fellows and 7 more are currently working in his group at the NIH. He has been a fantastic mentor of young scientists who have since spread across the globe, from Taiwan to China, from France to the Netherlands, from Canada to many places in the United States. Many flew into Washington DC to attend the funeral ceremony on February 9^th. Teh was attentive, supportive and kind, but at the same time, demanding to his postdocs. Importantly, he set himself as an unselfish role model for them, working essentially 7 days per week and regular working days ran from 7 am to 7 pm. But, also during the evening and at night, one never had to wait long for reply emails. He was truly interested and at many times influenced the future careers of those who were lucky enough to have spent some time in his laboratory. In fact, his words of advice reached many more individuals with whom he came across in his professional and private life. His mentoring commitment is also reflected in his service to many professional societies. For instance, Teh was a standing member of the AIDS Molecular and Cellular Biology (AMCB) Study Section, where he had a reputation for being strongly supportive of new investigators.

Teh always had a special interest in the area of scientific publication. For instance, in 1994 he joined the editorial board of the Journal of Biomedical Science (JBS) of the National Science Council of Taiwan, the country in which he was born. He was an avid advocate for ways to improve the journal’s Impact Factor. He left this journal in 2004 to free himself for an important new activity: the launch of the journal Retrovirology, where he served as Editor-in-Chief since the journal’s inception. From the earliest years, Teh was an advocate of the Open Access publishing format. In particular, at the helm of Retrovirology, Teh witnessed much skepticism in regard to Open Access publishing during the early years and indomitably championed the new publishing format while overcoming initial prejudice. Teh often referred to himself and his Editorial Board members as the ‘Young Turks’ of virology, pioneering a new and exciting publishing format. Unsurprisingly, his talent for kicking off new initiatives paid off and Retrovirology is currently among the highest cited journals in the field of virology, and all of this was achieved in less than 10 years. In addition, he served on the editorial board of numerous journals, including the Journal of Virology and the Journal of Biological Chemistry.

Teh – as all who knew him will attest – would never rest on his laurels and although Retrovirology had become a leader in its field, he pushed for more journal involvement with the retroviral community .… and Frontiers in Retrovirology was born in 2009. It was the first conference organized by a BioMed Central journal – another example of Teh taking the lead – and proved to be such a universal success that the 3^rd conference in the series will take place in September 2013 in the UK in Cambridge.

Teh was a scientist with a vision and a broad interest in all aspects of scientific endeavor. He also was a true scientific leader, initiating scientific debate, writing editorials, sitting on many committees, orchestrating new book volumes and organizing international meetings on diverse topics. For instance, he was president of the Society of Chinese Bioscientists in America (SCBA) in 2010 and voiced the strong opinion that the representation of Asian-American scientists in leadership positions should be increased. He was instrumental in the decision to take the 2011 SCBA conference to China.

He was the recipient of an extraordinary number of awards, most recently the International Retrovirology Association’s Dale McFarlin Award in 2011, BioMed Central’s Open Access “Editor of the Year” in 2010 and the John’s Hopkins University Woodrow Wilson Award in 2009. Teh was also elected to membership of prestigious societies such as the Academia Sinica in Taiwan, Fellowship in the American Academy of Microbiology, and Fellowship in the American Association for the Advancement of Science.

Teh had an infectious enthusiasm and winner’s mentality both at work and play. He was a skilled tennis and chess player, a gifted writer, and a great debater with strong opinions on virtually all subjects of science and life in general. Additionally, he had a passion for current events and a love of travel, movies, food and music.

Teh’s death is a blow to the retrovirus research community and we will sorely miss his scientific leadership. He has been central to so much of what we have accomplished together as well as being a supportive and generous friend to many of us individually. Teh’s life was much too short, but his legacy and our memories of him will last forever. Our hearts and condolences are with his wife Diane and his three children David (23), Diana (20), and John (15).