Volume 9 Supplement 2

AIDS Vaccine 2012

Meeting abstracts

AIDS Vaccine 2012. Go to conference site.

Boston, MA, USA9-12 September 2012

Concatenated PDF 9S2

Page 8 of 9

Identification of HIV-1-specific regulatory T cells using HLA-class-II tetramers

Authors: M Angin, PL Klarenbeek, M King, KW Wucherpfennig and MM Addo

Citation: Retrovirology 2012 9(Suppl 2):P279

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A high-dimensional immune monitoring model of HIV-1-specific CD8 T cell responses accurately identifies subjects achieving spontaneous viral control

Authors: ZM Ndhlovu, L Chibnik, J Proudfoot, S Vine, A McMullen, K Cesa, F Porichis, D Alvino, A Piechocka-Trocha, P De Jager, BD Walker and D Kaufmann

Citation: Retrovirology 2012 9(Suppl 2):P280

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The HIV-1 protective -35SNP effect in Caucasians is CD8 T cell mediated

Authors: T Corrah, S Brackenridge, N Goonetilleke, H Yang, S Deeks, L Dorrell, M Cohen and A McMichael

Citation: Retrovirology 2012 9(Suppl 2):P281

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HIV-1 selectively exploits cross-reactive CTL “help” to promote dysfunctional programming of pro-inflammatory dendritic cells

Authors: RB Mailliard, KN Smith, RJ Fecek, CR Zaccard, SC Watkins, G Rappocciolo, JI Mullins and CR Rinaldo

Citation: Retrovirology 2012 9(Suppl 2):P282

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Chronic progressive HIV-1 infection is associated with elevated levels of myeloid-derived suppressor cells

Authors: T Vollbrecht, J Roider, R Stirner, A Tufman, RM Huber, JR Bogner, A Lechner, C Bourquin and R Draenert

Citation: Retrovirology 2012 9(Suppl 2):P283

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Plasticity of HIV-specific CD8 T cell responses in untreated HIV-1 infection- a step towards a therapeutic vaccine against drug resistance mutations

Authors: J Roider, A Kalteis, T Vollbrecht, L Gloning, R Stirner, N Henrich, JR Bogner and R Draenert

Citation: Retrovirology 2012 9(Suppl 2):P284

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The early Th17/Treg ratio predicts the immune activation set point in patients with primary HIV infection

Authors: MF Chevalier, G Petitjean, C Didier, P Girard, L Meyer, F Barré-Sinoussi, D Scott-Algara and L Weiss

Citation: Retrovirology 2012 9(Suppl 2):P285

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Comparable antiviral capacity but favorable in vitro survival of CD8s from elite controllers compared to untreated progressors

Authors: D Shasha, F Porichis, K Daniel, O Angiuli, DE Kaufmann and B Walker

Citation: Retrovirology 2012 9(Suppl 2):P286

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Loss and regain of SIV control upon CD8+ cell depletion in vivo in SIV-controller macaques is not associated with efficient SIV specific CD8+ T-cells

Authors: C Hamimi, T Bruel, N Dereuddre-Bosquet, A Cosma, S Shin, A Corneau, P Versmisse, C Torres, B Delache, S Even, S Guenounou, B Targat, B Malleret, I Karlsson, F Barré-Sinoussi, R Le-Grand…

Citation: Retrovirology 2012 9(Suppl 2):P287

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Comparison of the depth of vaccine-elicited HIV-1 Env epitope-specific CD8+ T lymphocyte responses

Authors: SL Hulot, BT Korber, G Pantaleo, J Tartaglia, B Jacobs, B Perdiguero, CE Gomez, M Esteban, N Letvin, MS Seaman, B Haynes and S Santra

Citation: Retrovirology 2012 9(Suppl 2):P288

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Understanding the precursor frequencies of HIV-1 specific CD4+ T cells in seronegative donors

Authors: SL Campion, T Brodie, A Rossetti, N Goonetilleke, F Sallusto and A McMichael

Citation: Retrovirology 2012 9(Suppl 2):P289

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IL-7 abrogates memory T regulatory cell functions by modulation of CD39/ATP axis in vitro and in vivo in HIV infected and non-infected patients

Authors: M Younas, S Hue, M Surenaud, C Lacabaratz, A Guiguin, A Wiedman, S Becq, T Croughs, J Lelievre and Y Levy

Citation: Retrovirology 2012 9(Suppl 2):P290

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Construction of site selected phage library and characterization of anti-V3 scFvs from Indian clade C HIV-1 infected patient

Authors: R Kumar, R Andrabi, A Tiwari, P Somi Sankaran, N Wig, D Dutta, A Sankhyan, L Khan, S Sinha and K Luthra

Citation: Retrovirology 2012 9(Suppl 2):P291

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Improving immunogenicity of HIV-1 envelope gp120 by glycan removal and immune complex formation

Authors: R Kumar, M Tuen, H Li, DB Tse and CE Hioe

Citation: Retrovirology 2012 9(Suppl 2):P292

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Simian immunodeficiency virus-Vpx as an adjuvant for integrase defective lentiviral vector-based vaccines

Authors: M Blasi, A Rossi, Z Michelini, P Leone, G Perretta, A Cimarelli, ME Klotman, D Negri and A Cara

Citation: Retrovirology 2012 9(Suppl 2):P293

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Conservation of HIV-1 T cell epitopes across time and clades: validation of immunogenic HLA-A2 epitopes selected for the GAIA HIV vaccine

Authors: AS De Groot, K Sangare, O Koita, M Ardito, C Boyle, L Levitz, J Rozenhal, K Tounkara, S Dao, Y Kone, Z Koty, L Moise and W Martin

Citation: Retrovirology 2012 9(Suppl 2):P294

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Further confirmation of broadly conserved, highly immunogenic cross-clade HIV CTL epitopes for inclusion in the GAIA HIV vaccine

Authors: AS De Groot, L Moise, O Koita, K Sangare, L Levitz, J Rozenhal, Z Koty, K Tounkara, M Ardito, CM Boyle, M Rochas and W Martin

Citation: Retrovirology 2012 9(Suppl 2):P295

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Extensive glycoform heterogeneity in the gp120 envelope proteins used in the RV144 trial

Authors: B Yu, JF Morales, SM O’Rourke, GP Tatsuno and PW Berman

Citation: Retrovirology 2012 9(Suppl 2):P296

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Antigen processing sites in gp120 are conserved across HIV virus clades

Authors: B Yu, SM O’Rourke, JF Morales, GP Tatsuno, KA Mesa and PW Berman

Citation: Retrovirology 2012 9(Suppl 2):P297

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Development of chimeric HIV Env immunogens for mucosal delivery with attenuated canine distemper virus (CDV) vaccine vectors

Authors: X Zhang, S Richlak, HT Nguyen, O Wallace, G Morrow, M Caulfield and C Parks

Citation: Retrovirology 2012 9(Suppl 2):P298

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Stability and neutralization capacity of a novel mosaic HIV-1 gp140 trimer in a guinea pig model

Authors: JP Nkolola, JM Kovacs, B Korber, B Chen, M Seaman and D Barouch

Citation: Retrovirology 2012 9(Suppl 2):P299

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Targeting HIV-1 envelope glycoprotein trimers to B cells using APRIL improves antibody responses

Authors: M Melchers, I Bontjer, T Tong, N Chung, P Klasse, D Eggink, M Gentile, A Cerutti, D Montefiori, W Olson, B Berkhout, J Binley, J Moore and R Sanders

Citation: Retrovirology 2012 9(Suppl 2):P300

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The viral vector vaccine VSV-GP boosts immune response upon repeated applications

Authors: R Tober, Z Banki, A Ejaz, A Muik, L Egerer, D von Laer and J Kimpel

Citation: Retrovirology 2012 9(Suppl 2):P301

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Immune responses triggered by HIV/AIDS vaccine candidates, derived from MVA-B, with deletions in several immune regulatory genes

Authors: J García-Arriaza, P Arnáez, CE Gómez and M Esteban

Citation: Retrovirology 2012 9(Suppl 2):P302

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Systems analysis of MVA-C induced immune response reveals its significance as a vaccine candidate against HIV/AIDS of clade C

Authors: C Gómez, B Perdiguero, V Jimenez, A Filali-Mouhim, K Ghneim, E Haddad, E Quakkerlaar, J Delaloye, A Harari, T Roger, T Duhem, R Sekaly, C Melief, T Calandra, F Sallusto, A Lanzavecchia…

Citation: Retrovirology 2012 9(Suppl 2):P303

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A novel HIV vaccine targets the 12 protease cleavage sites

Authors: M Luo, D Tang, R Capina, X Yuan, C Prego, JC Pinto, M Alonso, C Barry, R Pilon, C Daniuk, J Tuff, S Pillet, D La, T Bielawny, C Czarnecki, P Lacap…

Citation: Retrovirology 2012 9(Suppl 2):P304

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A minimal T-cell immunogen designed to cover HIV-1 specificities associated with control is immunogenic in mice and breaks CTL immunodominance

Authors: B Mothe, A Llano, M Rosati, S Perez-Alvarez, V Kulkarni, B Chowdhury, C Alicea, RK Beach, NY Sardesai, GN Pavlakis, BK Felber and C Brander

Citation: Retrovirology 2012 9(Suppl 2):P305

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Control of HIV replication by a novel constitutively active ‘super-PRR’

Authors: S Gupta, J Termini and G Stone

Citation: Retrovirology 2012 9(Suppl 2):P306

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Conformational heterogeneity in V1/V2 domain affects the immunological properties of this region

Authors: A Pinter, AZ Wu, T Neubert, MD Burkhart and WJ Honnen

Citation: Retrovirology 2012 9(Suppl 2):P307

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Immunisation with the membrane proximal external region of gp41 of HIV-1 grafted into the transmembrane envelope protein of a gammaretrovirus

Authors: N Strasz, V Morozov, J Kreutzberger, M Lau and J Denner

Citation: Retrovirology 2012 9(Suppl 2):P308

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Development of a novel simian adenovirus 24 based vaccine vector

Authors: P Abbink, RR Bradley, F Ball, D Ng'ang'a, E Borducchi and DH Barouch

Citation: Retrovirology 2012 9(Suppl 2):P309

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Development of replication-competent adenovirus based vaccine vectors

Authors: P Abbink, LF Maxfield and DH Barouch

Citation: Retrovirology 2012 9(Suppl 2):P310

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IFN-γ secreting capacity of CD8+T cell is compromised with the increased copies of epitope encoding sequences in DNA vaccine design

Authors: J Wang, Y Wan and J Xu

Citation: Retrovirology 2012 9(Suppl 2):P311

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Potency of an HIV-SAM™ vaccine in a heterologous prime-boost vaccination regimen

Authors: K Banerjee, Y Cu, Y Sun, K Hartog, A Dey, L Brito, A Verma, A Nandi, P Sarkar, NM Valiante, AJ Geall, SW Barnett and GR Otten

Citation: Retrovirology 2012 9(Suppl 2):P312

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Antigenicity of soluble HIV gp140 trimers reveals differences in solution conformation for differing HIV strains

Authors: TL Gearhart, JD Steckbeck, RC Montelaro and JK Craigo

Citation: Retrovirology 2012 9(Suppl 2):P313

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Priming with DNA encoding functional trimers and boosting with soluble trimeric protein elicited tier 2 neutralizing antibodies in non-human primates

Authors: BK Chakrabarti, F Yu, K McKee, C Labranche, D Montefiori, JR Mascola and RT Wyatt

Citation: Retrovirology 2012 9(Suppl 2):P314

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A pantothenate suxotroph of BCG rxpressing Gag confers enhanced HIV-specific immunogenicity compared to wildtype and perfingolysin expressing strains

Authors: S Chetty, E Shephard, D Bowers, M Darby, W Horsnell, R Chapman and A Williamson

Citation: Retrovirology 2012 9(Suppl 2):P315

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Optimising CN54gp140 plasmid delivery by comparing intramuscular and intradermal vaccination combinations with and without electroporation

Authors: JF Mann, PF McKay, J Swales, K Klein, A Fiserova, A Cope and RJ Shattock

Citation: Retrovirology 2012 9(Suppl 2):P316

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A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 determinant for neutralization but not for antigen recognition

Authors: W Weissenhorn, D Lutje Hulsik, M Hock, YY Liu, NM Strokappe, ME Khattabi, JP Langedijk, LE McCoy, A Forsman-Quigley, MM Aasa-Chapman, RA Weiss, TC Verrips and L Rutten

Citation: Retrovirology 2012 9(Suppl 2):P317

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Transforming epitope-specific gp120 monomer-based probes into immunogens with N-linked glycan masking

Authors: G Chuang, JC Boyington, GJ Nabel, PD Kwong and I Georgiev

Citation: Retrovirology 2012 9(Suppl 2):P318

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Development of an imaging based virus aggregation assay for vaccine development

Authors: D Stieh, C Gioia, M McRaven, G Cianci, P Kiser and T Hope

Citation: Retrovirology 2012 9(Suppl 2):P319

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Molecular epidemiology of the protective RV144 V2 loop epitope

Authors: T Cardozo

Citation: Retrovirology 2012 9(Suppl 2):P320

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Novel strategies for HIV-1 epitope delivery using foamy viral hybrid proteins and vectors

Authors: M Mühle, A Bleiholder, K Hoffmann, M Löchelt and J Denner

Citation: Retrovirology 2012 9(Suppl 2):P321

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Immunogenic selection of HIV-1 MPER epitopes for improved vaccine design

Authors: L Wieczorek, M Rao, K Peachman, N Steers, M Marovich, N Michael, V Polonis and V Rao

Citation: Retrovirology 2012 9(Suppl 2):P322

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Antigenicity and immunogenicity of a novel, acute HIV-1 Tanzanian subtype C gp145 envelope protein for clinical development

Authors: V Polonis, L Wieczorek, V Kalyanaraman, G Matyas, S Whitney, C Williams, S Tovanabutra, E Sanders-Buell, M Wesberry, C Ochsenbauer, A Chenine, M Rao, T Tong, C Alving, H Cheng, S Zolla-Pazner…

Citation: Retrovirology 2012 9(Suppl 2):P323

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The emptied bacteriophage T4 head: a novel nanoparticle vehicle to simultaneously deliver HIV-1 antigens and genes into dendritic cells

Authors: V Rao

Citation: Retrovirology 2012 9(Suppl 2):P324

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The C-terminal tail of HIV-1 envelope: a unique role for conserved LLP arginines in Env functional properties

Authors: A Kuhlmann, JD Steckbeck, TJ Sturgeon, JK Craigo and RC Montelaro

Citation: Retrovirology 2012 9(Suppl 2):P325

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Yeast surface display of HIV Env protein variants for the discovery of novel vaccine immunogens

Authors: S Grimm and M Ackerman

Citation: Retrovirology 2012 9(Suppl 2):P326

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Development of candidate HIV vaccines using VSV vectors to express membrane-anchored MPER immunogen

Authors: M Yuan, A Wilson, M Kemelman, M Panis, I Lorenz, C Jurgens, MJ Chiuchiolo, R King, M Caulfield and CL Parks

Citation: Retrovirology 2012 9(Suppl 2):P327

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Vaccination with dendritic cells loaded with HIV-1 lipopeptides elicits broad T cell immunity and control of viral load in HIV infected patients

Authors: Y Levy, R Thiébaut, M Montes, C Lacabaratz, L Sloan, S Perusat, C Harrod, C Boucherie, S Zurawski, L Richert, G Chêne, J Banchereau and K Palucka

Citation: Retrovirology 2012 9(Suppl 2):P328

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