MicroRNAs and long non-coding RNAs during transcriptional regulation and latency of HIV and HTLV

Retrovirology

Table 2 Target and effects of cellular lncRNAs and miRNAs during HTLV transcriptional and post transcriptional events

lncRNA	Target	Outcome	References
hbz (viral)	CCR4, E2F1 and survivin	Promotes virus latency	[162, 163]
ANRIL	EZH2	Persistent activation of	[164]
		NF-κB pathway

miRNA	Target	Outcome	References
miR-28	Gag-pol RNA	Downregulation of HTLV	[166]
miR-155	TP53INP1	Apoptosis control	[173, 175]
miR-130b, miR-93
miR-34a	SIRT1, BAX	Apoptosis control	[176]
miR-31	NIK	Pro-apoptosis	[177]
miR-17, miR-21	OBFC2A–hSSB2	Abnormal cell proliferation	[181]

ISSN: 1742-4690