MicroRNAs and long non-coding RNAs during transcriptional regulation and latency of HIV and HTLV

Retrovirology

Table 1 Target and effects of cellular lncRNAs and miRNAs during HIV transcriptional and post transcriptional events

lncRNA	Target	Outcome	References
lncRNA ASP (viral)	EZH2, DNTMT3α and	Epigenetic control	[107]
	HDAC-1
RNA 7SK	pTEFb	Stabilizes pTEFb complex	[111]
NRON	NFAT	Decreases HIV transcription	[112]
HEAL	FUS	Increases HIV transcription by epigenetic regulation	[114]
MALAT-1	EZH2, miR-155,150-5p	Increases HIV transcription, favours HIV reactivation by epigenetic regulation	[115]
			[116]
AK130181	NF-κB	Decreases HIV transcription	[117]
NEAT-1	PSF, p54nrb	Paraspeckle formation and	[118]
	(Paraspeckle proteins)	HIV transcripts retention in nucleus
uc002yug.2	RUNX1	Increases HIV transcription	[121]
		by inhibiting a repressor and increasing Tat
GAS5	miR-873	Decreases HIV replication	[122]

miRNA	Target	Outcome	References
miR-28, miR-125b,	RNA viral genome	Downregulation of HIV expression	[136, 138,139,140,141, 233]
miR-150, miR-223, miR-382, miR-29a, miR-29b, miR-138, miR-149, miR-326, miR-196b, miR-1290
miR-198, miR-27b	CycT1	Downregulation of HIV transcription	[93, 142]
miR-642a	AFF4	Downregulation of HIV transcription	[143]
miR-15a, miR-15b,
miR-16, miR-20a,	Pur-α	Downregulation of HIV transcription	[145]
miR-106b, miR-93
miR-17, miR-20a	PCAF	Downregulation of HIV transcription	[146]
miR-155	ADAM10, TNPO3, TRIM32,	Downregulation of HIV transcription	[147, 148]
	NUP153, LEDGF/p75
miR-186, miR-210	HIV-EP2	Reduction of viral replication	[149]
miR-132	MeCP2	Upregulation of HIV transcription	[150]
miR-34a, miR-124a,	P21/TASK1	Upregulation of HIV transcription	[153]
miR-let-7c
miR-217, miR-34a	SIRT1	Upregulation of HIV transcription	[155, 156]
miR-9	BLIMP-1	Upregulation of HIV transcription	[158]
miR-146a	TRAF6, IRAK1	Upregulation of HIV replication	[161]

ISSN: 1742-4690