Fig. 2
From: The chemokine receptor CCR5: multi-faceted hook for HIV-1
Schematic representation of the factors that can influence the 3D-structure of CCR5 coreceptor. A Post-translational modifications (PMTs): sites of O-Glycosylation (Ser6, Thr16, Ser17) [70, 71], sulfation (Tyr3, 10, 14, 15) [73, 75,76,77,78], palmitoylation (Cys321, 323 and 324) [79,80,81,82,83,84,85,86,87,88,89,90,91] and phosphorylation (Ser336, 337, 342 and 349) [235, 236] are represented by colored circles. Factors such as G-protein coupling (B) [28, 60, 97,98,99,100,101,102,103], mutations (C) [126,127,128,129, 177, 178], surface density [117,118,119,120,121,122,123] and oligomerization [136,137,138,139,140,141,142,143,144,145,146,147,148,149] (D) and membrane surrounding [152,153,154,155,156,157,158,159,160,161,162,163,164,165,166,167,168,169,170,171,172,173] (E) are also exemplified