Table 1 HIV-1 p6 inhibitors targeting viral budding
From: The HIV-1 gag p6: a promising target for therapeutic intervention
Inhibitors | Targeting sites | Antiviral mechanism | References |
|---|---|---|---|
Cyclic peptide 11 | UEV domain of TSG101 | Inhibiting HIV budding by disrupting the interaction between Gag p6 and UEV domain of TSG101 | [40] |
Peptoid hydrazones and peptoid hydrazides | [42] | ||
Cyclic peptide KRL74 | [41] | ||
Peptide XY3-3 | [44] | ||
Esomeprazole and tenatoprazole | [45] | ||
TSG-5′ (TSG101 N-terminal with residues 10–240) | PTAP motif of Gag p6 | Blocking the binding of TSG101 to Gag p6, thereby inhibiting HIV budding | [39] |
Alix fragment (Residues 364–716) | YPXL motif of Gag p6 | Inhibiting HIV budding by blocking the binding of Alix to Gag p6 | [46] |