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Fig. 7 | Retrovirology

Fig. 7

From: DNA topoisomerase 1 represses HIV-1 promoter activity through its interaction with a guanine quadruplex present in the LTR sequence

Fig. 7

G4 are enriched in the positive strand of TOP1 repressed cellular genes. A, B Boxplots of G4Hunter maximum scores (score threshold > 1.7, window size = 25 nts) in the positive (A) or negative (B) strands of the TSS-500 bp-TSS of genes that are significantly up-regulated (FC > 1.5) (up) or for a same number of genes (104) which RNA levels are not modified (ctrl) in shTop1 versus shCtrl HCT116 cells (transcriptomic data from [65]). Differences between the scores of the two groups were tested with a Wilcoxon rank sum test of which p-values are reported on the graphs. (C-D) Same analysis performed in the positive (C) or negative (D) strands of the promoter sequences of up-regulated and same number of control genes (123) in A549 cells (transcriptomic data from [14])

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Retrovirology

ISSN: 1742-4690

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