Fig. 1
From: Conformational antigenic heterogeneity as a cause of the persistent fraction in HIV-1 neutralization
Neutralization efficacy of BG505 and B41 pseudovirus. The extent of neutralization (%) of PV in a TZM-bl assay is plotted as a function of NAb concentration (μg/ml); means ± s.e.m. of 2–4 replicate titrations are shown. Neutralization by the three bNAbs 2G12 (N332 glycan), PGT145 (V2-apex), and PGT151 (gp41-gp120 interface) of BG505 PV (A) and B41 (B) gave different potencies and efficacies. C The log10 of the relative remaining infectivity after neutralization by bNAb at a fixed concentration (50 μg/ml) is plotted as a function of the log10 of varied viral inoculum dilution. D The schematic shows the procedure for partial depletion of a PV preparation by the absorption of virions binding most avidly to bNAbs on beads