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Fig. 2 | Retrovirology

Fig. 2

From: HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity

Fig. 2

Comparison between SERINC5 down-regulation activity and the other Nef functions. A  The graph shows a statistically significant correlation (Spearman’s correlation) between SERINC5 down-regulation and CD4 down-regulation activities of patient-derived Nef clones, while graphs in panels B and C show no relationship between SERINC5 down-regulation activity and the activities of HLA-I down-regulation and alteration of TCR signalling. All Nef functions were expressed relative to that of SF2 Nef (100% activity)

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Retrovirology

ISSN: 1742-4690

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