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Table 1 Demographic and clinical characteristics of study groups (n = 88)

From: Anti-inflammatory effects of recreational marijuana in virally suppressed youth with HIV-1 are reversed by use of tobacco products in combination with marijuana

Characteristics

Youth without HIV-1

Youth with HIV-1 receiving ART

  

VL > 50

VL ≤ 50c

Reference

(n = 25)

Group I

(n = 9)

Group II

(n = 8)

Group III

(n = 19)

Group IV

(n = 8)

Group V

(n = 19)

Substance use

None

Marijuana + Tobacco + Alcohol

None

None

Marijuana

Marijuana + Tobacco

Group abbreviation

H–S−

H–S+[M/T/A]

H+V+S−

H+V−S−

H+V−S+[M]

H+V−S+[M/T]

THCA conc. (ng/ml)a

 ≤ 1

118 [50, 336]

≤ 1

≤ 1

122 [65, 242]

212 [167, 322]

Cotinine conc. (ng/ml)a

 ≤ 1

34 [13, 70]

≤ 1

≤ 1

≤ 1

40 [18, 45]

Years of regular usea

      

 Marijuana

NA

4.5 [3.0, 6.0]

NA

NA

7.5 [5.8, 10.8]

7.0 [5.0, 8.0]

 Tobacco

NA

4.5 [3.0, 6.0]

NA

NA

NA

7.0 [5.5, 10.3]

Age (years)a, #

22 [20, 23]

22 [20, 23]

24.5 [23, 25]

24 [23, 26]

23 [22, 25]

24 [22, 25]

Male (%)†

68

100

75

84

75

95

African American (%)‡

80

33

88

79

100

63

Years on ARTa, $

0

0

2.6 [2.2, 2.9]

2.9 [2.4, 2.9]

2.6 [1.4, 2.8]

2.6 [2.5, 2.9]

ART regimen (%)b, §

 PIs

NA

NA

88

63

63

79

 NRTIs

NA

NA

100

95

100

89

 NNRTIs

NA

NA

25

37

50

32

HIV-1 RNA

(copies/mL plasma)a

NA

NA

6959

[127, 19655]

 ≤ 50

 ≤ 50

 ≤ 50

CD4 Tcell count (cells/µL)a, ¶

 End of study

751 [462, 864]

692 [447, 873]

574 [307, 818]

736 [581, 964]

624 [522, 862]

688 [438, 850]

 Nadir

NA

NA

459 [269, 626]

451 [341, 490]

625 [416, 632]

360 [285, 501]

  1. NA: not applicable. PIs: protease inhibitors. NRTIs: nucleoside reverse transcriptase inhibitors. NNRTIs: non-nucleoside reverse transcriptase inhibitors
  2. aMedian [25th and 75th quartile range]
  3. bPercent of YWH (n = 54)
  4. cVirally suppressed YWH, who used tobacco only or combinations of other substances, were excluded from the analyses due to small sample size
  5. #Ages were similar between Reference Group and Group I (p = 0.6107) and among YWH groups (p = 0.7947). YWOH was younger than YWH (p < 0.0001)
  6. †Gender proportions were similar among study groups (p = 0.1611)
  7. ‡Proportions of African American were similar between YWOH and YWH (p = 0.3262) and within YWH groups (p = 0.1655) except that YWOH using substances had less proportion of African American in contrast to other groups (p = 0.0222)
  8. $Duration on ART was similar among YWH groups (p = 0.5069)
  9. §Types of ART were balanced across YWH groups (p = 0.9637)
  10. ¶CD4 T cell counts at end of study were similar among all groups (p = 0.7927) and nadir CD4 T cell counts were similar among YWH groups (p = 0.4208)