Fig. 5
From: A novel Betaretrovirus discovered in cattle with neurological disease and encephalitis
T-lymphocytes and macrophages contributed in high numbers to perivascular cuffs and gliosis. A–D Immunohistochemical analysis was performed with staining with an antibody targeting CD3. Positivity (red granular staining) is visible in the cytoplasm of CD3 + T-lymphocytes in perivascular cuffs (A case 6, medulla oblongata; B case 5, thalamus), diffuse gliosis (C case 6, medulla oblongata), and nodular gliosis (D case 6, hypothalamus). E, F Immunohistochemical analysis was performed with staining with an antibody targeting ionized calcium-binding adapter molecule 1. Positivity (red granular staining) is visible in the cytoplasm of cells in perivascular cuffs and ramified cells in the neuroparenchyma (microglia; E case 2, medulla oblongata; F case 4, thalamus)