Fig. 3
From: A novel Betaretrovirus discovered in cattle with neurological disease and encephalitis
Bovine retrovirus CH15–positive animals showed non-suppurative encephalitis on histopathological examination. Formalin-fixed paraffin-embedded brain tissue slides were stained with hematoxylin and eosin. A Perivascular infiltrates of mononuclear cells forming a cuff around a vessel; case 6, hypothalamus. B Nodular gliosis (arrows) around neurons; case 1, medulla oblongata. C Perivascular cuff with infiltration of mononuclear cells in the vessel wall (arrows); case 7, medulla oblongata. D Severe ecchymotic and ring hemorrhages, often in association with perivascular cuffs (asterisk); case 7, thalamus. E Chromatolytic, swollen, and eosinophilic motoneurons (arrowheads); case 6, medulla oblongata. F Eosinophilic and shrunken pyramidal cells with loss of Nissl substance (arrows) surrounded by hypertrophic astrocytes (arrowheads); case 7, hippocampus