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Fig. 4 | Retrovirology

Fig. 4

From: HIV-1 integrase binding to genomic RNA 5′-UTR induces local structural changes in vitro and in virio

Fig. 4

XL-SHAPE analysis of NC binding to the HIV-1 5′-UTR-ΔDIS/IN/IBD complex. The identified crosslinking sites are labeled by red stars. Sites with decreased and increased SHAPE reactivity upon protein binding are indicated by green and red arrowheads, respectively. All identified sites had reactivity changes of ≥ 0.3 and p < 0.05 based on unpaired, two-tailed Student’s t-tests, compared with the RNA + IN/IBD control. Results are based on the average of at least 3 independent experiments. Other information is as noted in the legend to Fig. 1

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