Impact of HIV-1 CRF55_01B infection on the evolution of CD4 count and plasma HIV RNA load in men who have sex with men prior to antiretroviral therapy

Table 3 Estimates of increasing rate of viral load from the time of diagnosis to cART initiation

	N	Increase rate of viral load (log₁₀copies/ml/year)			Increase rate of viral load (log₁₀copies/ml/year)
	N	Mean (95%CI)	P value	P value	Adjusted mean (95%CI)*	P value
CD4 200–350
CRF55_01B	29	3.5 (1.5, 5.5)	Ref		Ref	Ref
CRF01_AE	33	1.9 (0.9, 2.9)	0.150	Ref	− 1.4 (− 3.2, 0.4)	0.136
CRF07_BC	27	0.9 (0.5, 1.3)	< 0.05	< 0.05	− 2.6 (− 4.5, − 0.7)	< 0.05
CD4 ≥ 350
CRF55_01B	28	0.9 (0.6, 1.2)	Ref		Ref	Ref
CRF01_AE	21	1.4 (0.8, 2.0)	0.400	Ref	0.2 (− 0.2, 0.7)	0.345
CRF07_BC	28	0.7 (0.5, 0.9)	0.606	0.215	− 0.1 (− 0.5, 0.4)	0.769
All ≥ 200
CRF55_01B	65	2.0 (1.1, 2.9)	Ref		Ref	Ref
CRF01_AE	65	1.4 (0.8, 2.0)	0.324	Ref	− 0.5 (− 1.5, 0.4)	0.250
CRF07_BC	69	0.7 (0.5, 0.9)	< 0.05	< 0.05	− 1.2 (− 2.1, − 0.3)	< 0.01

* The Adjusted mean was estimated with adjustment of age at HIV diagnosis, ethnicity, marital status, and year of HIV diagnosis

ISSN: 1742-4690