Fig. 5

Associations between HLA class I allele expression and Gag-protease driven VRC. Gag-protease driven VRC of chronically infected participants from East Africa with subtype A1 infection were grouped according to a HLA-A, b HLA-B and c HLA-C class I alleles expressed. The box plots display VRC results arranged from lowest median VRC at the bottom and the highest median VRC at the top. Boundaries of the boxes indicate the interquartile ranges, while the whiskers display the maximum and minimum VRC values. The continuous vertical line on each graph indicates the median VRC (0.6560) for all subtype A1 viruses from East Africa. HLA-I alleles with a minimum of n = 5 are shown. Asterisks indicate HLA alleles that are significantly (p < 0.05) associated with either higher or lower VRC (Student's t-test). Median value for subtype A1 VRC is represented by the vertical line shown at the middle of the graph