Fig. 6

Schematic of MxB and CPSF6 involved in HIV-1 pre-integration complex nuclear import. a During HIV-1 pre-integration complex (PIC) nuclear import, CPSF6 (red) binds to HIV-1 CA (blue) and facilitates PIC nuclear import by assisting interaction of PIC and NUP358 (green). b MxB (purple) locates at the nuclear envelope, binds with NUP358, grabs HIV-1CA to form CPSF6-PIC-MxB complex and disrupts NUP358-PIC interaction, leading to lower nuclear import efficiency. c In the absence of CPSF6 binding to HIV-1 CA, MxB retains the ability to bind to CA but lose antiviral activity