Fig. 4

Interpolation between the extremes of the FMA models for the protease (genotype RU1) in complex with LPV. Blue-to-magenta bands correspond to the interpolation along the mode as represented as cartoon for backbone and as sticks for residues 30, 45, and 58, with blue corresponding to L76 state and magenta to V76 state. Green dashed line represents a hydrogen bond between residues D30 and K45. Mutated residue 76, here semi-transparent in yellow, as well as hydrogen atoms, here in gray, were not part of the FMA models and are here for representational purposes only