Restriction factors | Mechanism of restriction | ||
---|---|---|---|
HIV-1 | HTLV-1 | HTLV-2 | |
APOBEC3G | Inhibits viral transcription of Vif deficient HIV-1, by generating G to A mutations on nascent viral DNA [17]a | No restriction [26] | nr |
TRIM19/PML | Inhibits viral transcription [35] | Inhibits viral replication by targeting Tax-1 for proteasomal degradation [87] | Inhibits viral replication by targeting APH-2 for proteasomal degradation [40] |
SAMHD-1 | Inhibits viral transcription by depleting endogenous dNTP pool [16] | Induces apoptosis of HTLV-1 infected cells [90] | nr |
Tetherin/BST2 | Prevents viral particles release [15] | No restriction [91] | nr |
miR-28-3p | nr | Inhibits viral transcription by targeting gag/pol mRNA [93] | nr |
CIITA | Inhibits Viral trascription by targeting Tat and by recruiting RF in specific bodies [44, 101, 105] | Inhibits viral replication by targeting Tax-1 [106] |