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Table 4 Thermal denaturation studies of the six-helix bundles formed by mixtures of HR1 (N36) and HR2 (C34) peptides with or without resistance mutations

From: Mutations of Glu560 within HIV-1 Envelope Glycoprotein N-terminal heptad repeat region contribute to resistance to peptide inhibitors of virus entry

 

N36-C34

Tm (°C)

∆Tm (°C)

N36wt

46

–

N36-E560K

52

6

N36-E560D

43

− 3

N36-E560G

42

− 4

  1. Tm midpoint of the thermal unfolding transition; ΔTm change in Tm due to the mutation compared with the peptide without mutation
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Retrovirology

ISSN: 1742-4690

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