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Table 3 Susceptibilities of pseudoviruses containing E560K/D/G mutations to the broadly neutralizing Abs 2F5 and 4E10

From: Mutations of Glu560 within HIV-1 Envelope Glycoprotein N-terminal heptad repeat region contribute to resistance to peptide inhibitors of virus entry

Inhibitor selection

Mutants

2F5 (μg/mL)

4E10 (μg/mL)

IC50 ± SD

Ratio

IC50 ± SD

Ratio

N36/IZN36

LAIwt

> 50

1.00

> 25

1.00

E560K

6.26 ± 0.53

< 0.13

2.24 ± 0.153

< 0.073

T20

E560D

1.34 ± 2.52

< 0.027

0.17 ± 0.01

< 0.054

E560G

17.78 ± 0.10

< 0.36

6.61 ± 0.26

< 0.21

  1. The ratio is IC50 for the indicated pseudovirus/LAIwt pseudovirus
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Retrovirology

ISSN: 1742-4690

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