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Table 2 Inhibition of pseudoviruses with resistance mutations by HR2 peptide inhibitor, T20

From: Mutations of Glu560 within HIV-1 Envelope Glycoprotein N-terminal heptad repeat region contribute to resistance to peptide inhibitors of virus entry

 

T20 (nM)

IC50 ± SD

Ratio

p value

LAIwt

138.34 ± 39.45

1.00

 

L544S

8248 ± 682.35

59.62

< 0.001

G547D

1749.02 ± 233.44

12.64

< 0.001

E560G

61.71 ± 11.71

0.45

0.0057

L544S G547D

25,310.03 ± 2985.82

182.96

< 0.001

L544S E560G

3006.20 ± 548.26

21.73

< 0.001

G547D E560G

1753.74 ± 340.63

12.68

0.0022

L544S G547D E560G

> 76,800

> 555.16

< 0.001

L544S G547D E560D

31,012.25 ± 3364.73

224.18

< 0.001

  1. The ratio is IC50 for the indicated pseudovirus/LAIwt pseudovirus
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Retrovirology

ISSN: 1742-4690

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