Reduction of inflammation and T cell activation after 6 months of cART initiation during acute, but not in early chronic HIV-1 infection

Table 1 Demographic and clinical characteristics of study participants

	HIV-neg (n = 18)	LcHI (n = 18)	EcHI (n = 11)	AHI (n = 12)	Total (n = 59)	P value
Age						0.001
Median (IQR)	37.1 (31.6; 49.3)	44.2 (40;49.8)	28.3 (26.7;29.9)	30.6 (27.7;39.5)	34.5 (27.9;46.5)
Gender (%)						< 0.001
Female	9 (50)	7 (38.9)	0 (0)	0 (0)	16 (27.1)
Male	9 (50)	11 (61.1)	11 (100)	12 (100)	43 (72.9)
HIV-1 viral load						< 0.001
Log₁₀, median (IQR)	NA	1.6 (1.6;1.6)	4 (3.7;4.9)	5.9 (4.8;6.5)	3.5 (1.6;4.9)
CD4 + T cell count						0.001
Cells/mm³, median (IQR)	831 (757.2;1129.5)	853 (762;983)	566 (389;666.5)	634 (484.2;885.5)	784 (648;909)

Analyses with age, HIV-1 viral load and CD4⁺ T cell count were performed using the Kruskal–Wallis
To EcHI and AHI we analyzed the pre-ART visit and for LcHI a pos-cART visit (median of 5 years after cART initiation)
Analyses with gender were performed using Fisher’s exact test
LcHI late chronic HIV-1 infection; EcHI early chronic HIV-1 infection; AHI acute HIV-1 infection; NA not applicable; IQR interquartile range

ISSN: 1742-4690