Table 4 Distribution of frequencies of alleles, genotypes and haplotypes of the MBL2 gene between monoinfected and coinfected patients
From: MBL2 gene polymorphisms in HHV-8 infection in people living with HIV/AIDS
Variables | HIV/HHV-8 n = 124 (%) | HIV n = 213 (%) | p valuea | OR (95% CI) |
|---|---|---|---|---|
Promoter (-550) | ||||
Alleles | ||||
L | 173 (70) | 297 (70) | – | Reference |
H | 75 (30) | 129 (30) | 1.0 | 1.0 (0.7–1.4) |
Genotypes | ||||
LL | 62 (50) | 102 (48) | – | Reference |
HL | 49 (40) | 93 (44) | 0.5 | 1.1 (0.7–1.8) |
HH | 13 (10) | 18 (8) | 0.7 | 0.8 (0.4–1.8) |
Promoter (-221) | ||||
Alleles | ||||
Y | 210 (85) | 356 (84) | – | Reference |
X | 38 (15) | 70 (16) | 0.7 | 1.1 (0.7–1.7) |
Genotypes | ||||
YY | 89 (72) | 148 (70) | – | Reference |
YX | 32 (26) | 60 (28) | 0.6 | 1.1 (0.7–1.9) |
XX | 3 (2) | 5 (2) | 0.6 | 1.0 (0.2–4.3) |
Exon-1 (52, 54, 57) | ||||
Alleles | ||||
A | 196 (79) | 344 (81) | – | Reference |
O | 52 (21) | 82 (19) | 0.6 | 0.9 (0.6–1.3) |
Genotypes | ||||
AA | 81 (65) | 143 (67) | – | Reference |
AO | 34 (28) | 58 (27) | 0.9 | 1.0 (0.6–1.6) |
OO | 9 (7) | 12 (6) | 0.5 | 0.7(0.3–1.9) |
Haplotypes | ||||
High expression | 46 (37) | 78 (36) | – | Reference |
Intermediate expression | 69 (56) | 123 (58) | 0.8 | 1.0 (0.7–1.7) |
Low expression | 9 (7) | 12 (6) | 0.6 | 0.8 (0.3–2.0) |