Table 2 Treatment status and baseline natural integrase polymorphisms of the HIV-1 recombinant viruses used for the in vitro selections with integrase inhibitors
Sample ID | GenBank accession number | Treatment status | Integrase baseline polymorphisms |
|---|---|---|---|
E78001 | MH513660 | ART-naïve | D10E, V31I, L68LV, V72I, I73IV, T112IT, I113V, G123S, R127K, I162IV, V201I, N232D, R284GR |
E78003 | MHS13661 | ART-naive | D10E, E11D, S24N, V31IV, V32I, L45IL, V72I, L101I, T112A, S119PRST, T122IT, G123S, A124AT, R127K, K136KN, V201IV, N232D |
E78004 | MHS13662 | ART-naïve | D10AE, E11D, V37I, K111A, T112A, S119P, G123S, A124T, T125A, R127K, V201IV, T206S, I208IL, N232D |
E78005 | MHS13663 | ART-naive | D10E, V72I, L101I, G123S, A124T, R127K, I203M, T206ST, N232D |
E78060 | MHS13664 | ART-naive | L45V, V72I, L74I, L101I, S119G, G123S, A124T, R127K, A128AT, N232D |
E78110 | MHS13665 | ART-naive | D10E, E11D, V31I, A91AT, L101I, S119T, G123S, A124T, R127K, K156N, E157Q, F181L, V201I, K211R, N232D, A265AV, I268IL |
E102430†(subtype D) | MHS13666 | INSTI (DTG)-experienced | D10E, S17N, K34KR, L45I, V72I, L101I, T112V, G123S, T125A, R127K, G134DG, I141IV, E157Q, K160E, D167E, G193E, V201I, I220V, N232D, L234I, D270DN, D288N |
E102952†(subtype D) | MHS13667 | INSTI (DTG)-experienced | D10E, S17N, K34KR, L45I, V72I, L101I, T112IV, G123S, T125A, R127K, E157Q, K160E, D167E, G193E, V201I, I220V, N232D, L234I, D288N |
E103211* | MHS13668 | INSTI-naive | D10E, S17N, V31I, V72I, L101I, K111R, T112A, S119RS, T122IT, G123CS, A124N, R127K, E157Q, K160Q, V201I, K215N, N232D, D256E, S283GS |
E103212* | MHS13669 | INSTI-naive | D10E, S17N, V31I, V72I, L101I, K111R, T112A, S119RS, T122IT, G123CS, A124NT, T125AT, R127K, E157Q, K160Q, V201I, K215N, N232D, D256E |