Table 1 Parameters linked to the development of broadly neutralizing antibodies

Tfh

 Frequency

[50]

 Quality

[50, 52, 61, 69]

 Phenotype / specificity

[50, 61, 69]

B-cells

 Precursor frequency

[40, 94, 95, 97, 106, 107, 116]

 BCR affinity for antigen

[37, 40, 107]

 Isotype class

[98]

 Amount of help received by Tfh

[36, 40, 44, 52]

Antigen

 Persistence

[76, 106]

 Diversity

[69]

Tregs/Tfr

 Frequency

[53, 90, 91]