Table 6 Levels of in vitro resistance for HIV-1 INSTI mutated viruses with raltegravir resistance pathways
From: HIV drug resistance against strand transfer integrase inhibitors
Genotype | RAL | EVG | DTG | CTG | BIC |
|---|---|---|---|---|---|
Y143 | |||||
Y143C | + | − | − | − | − |
L68V/Y143C | ++ | − | − | NA | − |
L68V/L74M/Y143C | +++ | ++ | − | NA | − |
L74M/T97A/E138A/Y143C | ++ | NA | − | NA | |
Q95K/Y143C | + | − | NA | NA | NA |
T97A/Y143C | +++ | + | − | NA | − |
T97A/Y143C/G163R | ++ | + | NA | NA | NA |
L74M/T97A/Y143G | ++ | NA | − | NA | NA |
Y143H | − | − | − | − | NA |
Y143K | + | NA | NA | NA | NA |
T97A/E138A/Y143K | ++ | NA | NA | NA | NA |
T97A/Y143S | + | NA | NA | NA | NA |
Y143S/V201I | + | NA | NA | NA | NA |
Y143R | ++ | + | − | − | − |
V72I/Y143R/T206S | ++ | NA | NA | NA | NA |
T97A/Y143R | +++ | ++ | − | NA | − |
L74M/T97A/Y143R | NA | NA | − | NA | NA |
L74M/T97A/E138A/Y143R | ++ | − | NA | NA | |
L74M/T97A/E138D/Y143R/G163N | +++ | ++ | NA | NA | |
G140S/Y143R | ++ | NA | NA | NA | NA |