Fig. 6

Protease inhibitors duranavir and lopinavir docked to the active site cavity of the viral proteases. a Darunavir (in blue) as in observed in the ultrahigh-resolution crystal structure (2HS1) and b Lopinavir (cyan) as bound to HIV-1 protease dimer. The semi-transparent surface of the active site cavity is shown using the color of the near atom. Ribbons are colored cyan and pink to represent the different monomers. c, d Models of these inhibitors docked to HERV-K protease. Carbon atoms of the HIV-1 protease are colored cyan, the conserved residues in HERV-K instead are colored green and the non-conserved red. Oxygen atoms are colored red and nitrogen blue