Table 1 Effect of compounds on HIV-1 gene expression and cell viability
From: Identification of small molecule modulators of HIV-1 Tat and Rev protein accumulation
| Â | HeLa | 24STNLESG | CEM-GXR | PBMC | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
|  | IC50 (μM) | CC50 XTT (μM) | CC50 Trypan blue (μM) | IC50 | CC50 XTT | IC50 | CC50 FSC/SSC (μM) | CC50 ViaCount (μM) | IC50 (μM) | CC50 Trypan blue (μM) |
791 | 8.2 | >40 | >40 | 26 μM | >60 μM | 4.5 μM | >12 | 24 | 1.5 | > 10 |
833 | 0.6 | ≥40 | >10 | 3.5 μM | >20 μM | 1.0 μM | >5 | >5 | 1.6 | 3.0 |
892 | 1.8 | >40 | >40 | nd | nd | n/a | 31 | 60 | 2.0 | 4.5 |