Fig. 8
HIV signaling through CD4 and CCR5 alters the landscape of GTPase-regulating proteins. a Rho family GTPases are regulated by guanine dissociation inhibitors (GDIs), guanosine exchange factors (GEFs), and GTPase activating proteins (GAPs). GTPase-regulating proteins with ±0.5 log2 fold changes in phosphopeptide expression levels following HIV-1 signaling via CD4 and CCR5 as compared to a microvesicle control are listed. b Log2 fold changes in intensity of phoshopeptides from GTPase-regulating proteins 1 min after exposing cells to inactivated HIV-1 viruses