Multiple HIV-1/M + HIV-1/O dual infections and new HIV-1/MO inter-group recombinant forms detected in Cameroon

Retrovirology

Table 2 Resistance profiles of the 10 samples presenting a dual infection HIV-1/M+O and/or a HIV-1/MO recombinant form

Samples	Profile	Protease	RT	Resistance associated mutations and resistance interpretation^a
				HIV-1/M species			HIV-1/O species
				Protease	RT	Resistance profile^b	Protease	RT	Resistance profile
YBF221	Dual	M + O	M + O	K20I M36I L63P/L L89M	V90I		L10V L33I M36I M46L/M I62V A71V K20C L63T L89T	T69S M184V A98G V179E Y181C L210Y	ATV, IDV, 3TC/ FTC, NNRTI LPV, SQV, ABC
YBF280	Dual	M + O	M + O	K20I M36I V77I L89M	None		L10V V11I I15V M36I I62V A71V K20C D60N/S L63I L89I	A98G K103R V179E L210Y	SQV ATV
YBF301	Dual	M + O	M + O	L10V K20I L24L/I M36I L89M	None	SQV	L10V I15V M36I I62V A71V K20C L63T/A L89M	M184V A98G K103R V179E Y181C L210Y	SQV, 3TC/FTC, NNRTI ATV, ABC
YBF320	Dual	M + O	M + O	K20I M36I L89M	K101Q		L10I/V I15V M36I I62V A71V K20C L63T L89I	A98G V179E Y181C L210Y	SQV, NNRTI ATV
YBF211	Dual + recombinant	M + O	M + O	I15L K20I M36I L63P L89M	None		L10V I15V M36I I62V A71V K20C L63T L89I	A98G V179E Y181C L210Y	SQV, NNRTI ATV
YBF212	Dual + recombinant	M + O	M + O	K20I M36I L89M	E138A V179I K101Q	RPV ETR	L10I I15V L33V M36I I62V A71V/I K20C F53Y/C D60S L63A L89I	A98G V179E Y181C L210Y	ATV, SQV, NNRTI
YBF205	Dual + recombinant	M + O	O	K20I L24L/I M36I L89M		SQV	L10I I15V M36I I62V A71V K20C D60N/S L63T L89I	A98G K103R V179E L210Y	SQV ATV
YBF274	Single + Recombinant	O	O	–	–		L10V/I I15V M36I D60E I62V A71V K20C L63T L89I	A98G V179E Y181C L210Y	ATV, SQV, NNRTI
YBF298	Single + recombinant	M	M	K20I D30N M36I D60N G73S L89M	None	NFV SQV	–	–	–
YBF282	Recombinant alone	M	M	G16E K20I M36I L63P/L L89M	None		-	-

ISSN: 1742-4690