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Table 2 Resistance profiles of the 10 samples presenting a dual infection HIV-1/M+O and/or a HIV-1/MO recombinant form

From: Multiple HIV-1/M + HIV-1/O dual infections and new HIV-1/MO inter-group recombinant forms detected in Cameroon

Samples Profile Protease RT Resistance associated mutations and resistance interpretationa
HIV-1/M species HIV-1/O species
Protease RT Resistance profileb Protease RT Resistance profile
YBF221 Dual M + O M + O K20I M36I L63P/L L89M V90I   L10V L33I M36I M46L/M I62V A71V K20C L63T L89T T69S M184V A98G V179E Y181C L210Y ATV, IDV, 3TC/ FTC, NNRTI LPV, SQV, ABC
YBF280 Dual M + O M + O K20I M36I V77I L89M None   L10V V11I I15V M36I I62V A71V K20C D60N/S L63I L89I A98G K103R V179E L210Y SQV ATV
YBF301 Dual M + O M + O L10V K20I L24L/I M36I L89M None SQV L10V I15V M36I I62V A71V K20C L63T/A L89M M184V A98G K103R V179E Y181C L210Y SQV, 3TC/FTC, NNRTI ATV, ABC
YBF320 Dual M + O M + O K20I M36I L89M K101Q   L10I/V I15V M36I I62V A71V K20C L63T L89I A98G V179E Y181C L210Y SQV, NNRTI ATV
YBF211 Dual + recombinant M + O M + O I15L K20I M36I L63P L89M None   L10V I15V M36I I62V A71V K20C L63T L89I A98G V179E Y181C L210Y SQV, NNRTI ATV
YBF212 Dual + recombinant M + O M + O K20I M36I L89M E138A V179I K101Q RPV ETR L10I I15V L33V M36I I62V A71V/I K20C F53Y/C D60S L63A L89I A98G V179E Y181C L210Y ATV, SQV, NNRTI
YBF205 Dual + recombinant M + O O K20I L24L/I M36I L89M   SQV L10I I15V M36I I62V A71V K20C D60N/S L63T L89I A98G K103R V179E L210Y SQV ATV
YBF274 Single + Recombinant O O   L10V/I I15V M36I D60E I62V A71V K20C L63T L89I A98G V179E Y181C L210Y ATV, SQV, NNRTI
YBF298 Single + recombinant M M K20I D30N M36I D60N G73S L89M None NFV SQV
YBF282 Recombinant alone M M G16E K20I M36I L63P/L L89M None   - -  
  1. aAccording to the ANRS resistance interpretation’s algorithm v25
  2. bIn underline = resistance; italic = possible resistance