Table 4 Recovery of integrated viral DNA from cells infected with the IN mutant G140S/Q148H
From: Drug resistant integrase mutants cause aberrant HIV integrations
HOS cells, drug concentration | Aberrant integration | Normal integration | % Aberrant integration | 1-LTR (aberrant 1-LTR) | 2-LTR (aberrant 2-LTR) | Autointegrants (aberrant circles) | Total no. of samples recovered and sequenced |
|---|---|---|---|---|---|---|---|
No drug | 5 | 56 | 8.2 | 72 (17) | 25 (5) | 7 (50) | 288 |
RAL IC50 | 5 | 66 | 7 | 38 (6) | 32 (15) | 9 (85) | 288 |
RAL IC75 | 7 | 45 | 13.5 | 56 (10) | 38 (13) | 6 (72) | 288 |