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Table 4 Recovery of integrated viral DNA from cells infected with the IN mutant G140S/Q148H

From: Drug resistant integrase mutants cause aberrant HIV integrations

HOS cells, drug concentration Aberrant integration Normal integration % Aberrant integration 1-LTR (aberrant 1-LTR) 2-LTR (aberrant 2-LTR) Autointegrants (aberrant circles) Total no. of samples recovered and sequenced
No drug 5 56 8.2 72 (17) 25 (5) 7 (50) 288
RAL IC50 5 66 7 38 (6) 32 (15) 9 (85) 288
RAL IC75 7 45 13.5 56 (10) 38 (13) 6 (72) 288
  1. RAL IC50: 4.25 µM