Table 2 Recovery of integrated viral DNA from cells infected with the IN mutant Y143R
From: Drug resistant integrase mutants cause aberrant HIV integrations
HOS cells, drug concentration | Aberrant integration | Normal integration | % Aberrant integration | 1-LTR (aberrant 1-LTR) | 2-LTR (aberrant 2-LTR) | Autointegrants (aberrant circles) | Total no. of samples recovered and sequenced |
|---|---|---|---|---|---|---|---|
No drug | 2 | 62 | 3.1 | 94 (19) | 12 (9) | 9 (55) | 288 |
RAL IC50 | 4 | 35 | 10.2 | 87 (7) | 23 (18) | 8 (75) | 288 |
RAL IC75 | 4 | 42 | 8.7 | 83 (17) | 40 (11) | 4 (61) | 288 |