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Table 2 Recovery of integrated viral DNA from cells infected with the IN mutant Y143R

From: Drug resistant integrase mutants cause aberrant HIV integrations

HOS cells, drug concentration Aberrant integration Normal integration % Aberrant integration 1-LTR (aberrant 1-LTR) 2-LTR (aberrant 2-LTR) Autointegrants (aberrant circles) Total no. of samples recovered and sequenced
No drug 2 62 3.1 94 (19) 12 (9) 9 (55) 288
RAL IC50 4 35 10.2 87 (7) 23 (18) 8 (75) 288
RAL IC75 4 42 8.7 83 (17) 40 (11) 4 (61) 288
  1. RAL IC50: 425 nM