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Table 1 Recurrent mutations in HERV-W subgroup 2 LTRs

From: Contribution of type W human endogenous retroviruses to the human genome: characterization of HERV-W proviral insertions and processed pseudogenes

Position (nt)a

Substitutionb

Frequencyc

PVd subgroup 2

PGe subgroup 2

Solo LTRs subgroup 2

Subgroup 1

43

C>T

100

100

98

0.7

95

C>T

100

95.8

96

3.4

100

T>C

97.3

100

95

2.2

180

C>T

97.3

100

95

0

254

A>G

97.3

96

87

1.4

706

A>G

97.4

73.3

88

1.7

765

G>A

95

73.3

90

1.7

  

Frequencyc

Position (nt)

Substitutionb

PVd subgroup 2A

PVd subgroup 2B

Subgroup 1

Type 2A additional mutations

    

456

C>T

100

41.7

10.5

498

A>G

92.6

33.3

3.5

Position (nt)a

Substitutionb

PVd subgroup 2B

PVd subgroup 2A

Subgroup 1

Type 2B additional mutations

    

133

A>G

100

48.1

0

188

C>A

90

19.2

0

252

C>G

90

40.7

1.7

  1. aNucleotide positions are referred to RepBase Update LTR17consensus
  2. bSubstitutions are indicated with the original nucleotide and the acquired new variant separate by the symbol >
  3. cRelative percentage based on the total of sequences that hold the position in an alignment
  4. dProviruses
  5. ePseudogenes