Fig. 4

Transmitter and recipient viruses show no significant difference in replicative capacity in PBMCs and MDMs. Replicative capacity of transmitter and recipient virus isolates in CD8-depleted PBMCs and monocyte-derived macrophages (MDMs). Replicative capacity was quantified as area under the curve (AUC) of p24 antigen production in culture supernatants over a 14 day period. a, c Median AUCs for 2 PBMC pools and 12 MDM donors between transmitter and recipient viruses were tested for statistical significance with a Wilcoxon matched-pairs signed rank test. b, d AUCs of recipient virus isolates expressed relative to their corresponding transmitter virus isolate. Values above and below the dotted line indicate when recipient viruses have a higher and lower replicative capacity, respectively. Independent experiments are indicated by different symbols