Fig. 2

Panobinostat administration induces systemic histone acetylation. NSG/BLT mice were administered panobinostat (2 mg/kg, n = 3) or vehicle (n = 5) intraperitoneally. After 24 h, tissues were harvested, and cells were isolated and resuspended in 1 % Triton-X/PBS. Cell lysates were analyzed for histone acetylation by ELISA. a Data from individual tissues. b Data from all tissues. Median and interquartile range plotted with comparisons by Mann–Whitney test: ns p > 0.05, *p < 0.05, ****p < 0.0001. Green circles denote control; mustard squares denote panobinostat-treated