Fig. 2

Jensen–Shannon divergence is correlated with both mean genetic diversity and the absolute difference in genetic diversity. The relationship between Jensen–Shannon divergence and genetic diversity (order = 1) in HIV-1 gp120, Tat, and LTR sequences was evaluated using Spearman’s rank correlation. Both the mean diversity of R5- and X4-classified sequences and the absolute difference between R5 and X4 diversity correlated with Jensen–Shannon divergence. This result indicates that large divergence can be a reflection of not only increased amounts of information (as indicated by high mean diversity), but also by the loss of information in one of the two groups (as indicated by the absolute difference in mean diversity)