Fig. 5

Antiviral activities of RPV and the RPV analogs against mutants selected by RPV. The IC₅₀ values for RPV and the RPV analogs against mutants selected by RPV were measured by using a single round infection assay. Error bars represent the standard deviations of independent experiments, n = 4. The IC₅₀ values of the graph are at a maximum value of 100 nM. The IC₅₀ value of several of the RPV analogs against the RPV resistant mutants were beyond the point of detection in our single round infection assay, >100 nM