Fig. 4

Antiviral activities of RPV and RPV analogs against mutants selected by RPV. The IC₅₀ values of RPV and the RPV analogs were measured against mutants found in RPV-treated patients (K101E, E138K, M184I, M184V, K101E/M184I, K101E/M184V, E138K/M184I, and E138K/M184V) or selected by RPV in cell culture (E40K, D67E, and V111A) using a single round infection assay. Error bars represent the standard deviations of independent experiments, n = 4. The IC₅₀ values of the graph are at a maximum value of 100 nM. To better illustrate the lower IC₅₀ values, the Y-axis is broken from 10 to 20 nM and also shown in the corresponding bars