Fig. 4

The most frequently recognized amino acid sequences on the envelope of P08 and P11. The sequences are aligned to the full-length transmitted/founder HIV-1 envelope from P08 and P11 and compared with and numbered according to HXB2. The predominantly recognized amino acid sequences are underlines. Those highlighted in red, blue and green boxes represent the piece of sequences transplanted into the CNE6 backbone to generate various chimeric viruses. The signal peptide, hypervarible regions V1–V5, interspersed conserved regions C1–C5 in gp120, immune dominant (ID), MPER and transmembrane domain (TM) in gp41 are also indicated