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Table 1 Conservation of V3 loop residues in HIV Env sequences from the Los Alamos database for A) all clades and B) clade CRF02_AG

From: Mechanisms of escape from the PGT128 family of anti-HIV broadly neutralizing antibodies

A: All clades

Position

Donor 36

1

2

3

4

295

N

N* (50.2)

I (12.9)

V (12.6)

T (8.8)

301

N*

N* (79.1)

N (10.5)

G (2.1)

T (1.4)

307

V

I (61.4)

V (16.8)

S (8.8)

M (3.7)

308

H

R (34.9)

H (25.1)

I (8.6)

T (6.9)

320

G

G (75.1)

T (8.1)

N (6.2)

E (2.7)

321

E

D (45.0)

E (22.7)

A (7.2)

Q (5.5)

322

V

I (89.4)

V (6.9)

G (1.0)

T (0.4)

325

N

D (78.3)

N (16.9)

I (1.2)

K (0.8)

326

P

I (94.6)

T (1.2)

G (1.0)

P (0.8)

330

F

H (68.9)

Y (25.7)

F (1.8)

Q (1.1)

332

T

N* (69.9)

E (8.5)

T (5.9)

N (4.8)

334

N*

S (69.4)

N* (23.2)

T (2.8)

N (2.2)

B: clade CRF02_AG

Position

Donor 36

1

2

3

4

295

N

N* (68.6)

T (10.7)

I (9.1)

N (4.1)

301

N*

N* (83.4)

N (5.8)

G (3.3)

K (1.6)

307

V

V (62.8)

I (21.5)

S (6.1)

G (2.5)

308

H

R (64.5)

H (20.7)

V (5.8)

M (1.7)

320

G

G (81.8)

T (6.6)

N (3.3)

D (3.3)

321

E

D (56.2)

E (21.5)

A (7.4)

G (5.0)

322

V

I (90.1)

V (7.4)

T (0.8)

Y (0.8)

325

N

D (71.9)

N (24.0)

G (2.5)

K (1.7)

326

P

I (96.7)

D (1.7)

T (0.8)

K (0.8)

330

F

H (74.4)

Y (21.5)

S (1.7)

Q (0.8)

332

T

N* (81.0)

T (6.6)

N (4.1)

K (1.7)

334

N*

S (81.8)

N* (14.9)

T (1.7)

V (0.8)

  1. Values are based on 4907 and 121 sequences from the Los Alamos database for all clades and clade CRF02_AG respectively. Values are reported as  % occurrence and only the four most frequent residues are shown. N* refers to asparagine residues that are part of a glycosylation sequon and N refers to asparagine residues that are not
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