Fig. 5

Alignment of BLV 5′LTR nucleotide sequences. Alignment of 5′LTR nucleotide sequences from a total of 16 South American BLV strains, including one, seven, and eight samples from Peru, Paraguay, and Bolivia, respectively, together with that of the FLK-BLV strain pBLV913. Strains from South America are shown by location of sample collection and sample ID. Identity with the FLK-BLV strain is indicated by dots. The U3, R, and U5 regions are indicated above the alignment. The three TxRE enhancer regions are shown in green, cyclic AMP-responsive element (CRE) sequences are underlined, and E-Box sequences are shown in italics. Binding sites for PU.1/Spi-B are shown in bold. The glucocorticoid responsive element (GRE) binding site is shown in bold and underlined. Nuclear factor κB (NF-κB) binding sites are shown double underlined. The CAT box and GATAA box promoters (PROMT) sequences are indicated in yellow and in bold italics, respectively. The polyadenylation site (PAS) is shown in grey and the CAP site is shown in blue. The downstream activator sequence (DAS) and the interferon regulatory factor (IRF) binding sites are shown in pink and light pink, respectively