Table 1 Top up regulated transcripts in CCR4+CCR6+ Th17 versus CXCR3+CCR6− Th1
Symbol | p | adj. p | FC | Gene definition |
|---|---|---|---|---|
IL-22 | 1.0E−04 | 4.0E−03 | 11.9 | Interleukin 22 |
CCR6 | 1.7E−06 | 3.7E−04 | 9.7 | Chemokine (C–C motif) receptor 6 |
PTPN13 | 1.5E−09 | 8.9E−06 | 9.6 | Protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) |
KLRB1 | 1.5E−05 | 1.2E−03 | 7.0 | Killer cell lectin-like receptor subfamily B, member 1 |
IL-17F | 5.9E−05 | 2.9E−03 | 6.6 | Interleukin 17F |
CCL20 | 3.2E−04 | 8.2E−03 | 6.6 | Chemokine (C–C motif) ligand 20 |
RORC | 2.1E−05 | 1.5E−03 | 6.6 | RAR-related orphan receptor C, transcript variant |
IL-26 | 9.3E−06 | 9.3E−04 | 5.1 | Interleukin 26 |
GPR56 | 1.4E−03 | 2.0E−02 | 4.9 | G protein-coupled receptor 56, transcript variant 2 |
LGMN | 1.6E−05 | 1.3E−03 | 4.5 | Legumain, transcript variant 2 |
CTSH | 1.5E−03 | 2.1E−02 | 4.4 | Cathepsin H, transcript variant 1 |
KLF2 | 1.7E−03 | 2.2E−02 | 3.8 | Kruppel-like factor 2 (lung) |
RARRES3 | 4.9E−03 | 4.3E−02 | 3.5 | Retinoic acid receptor responder 3 |
Ly9 | 8.6E−06 | 8.8E−04 | 3.5 | Lymphocyte antigen 9, transcript variant 2 |
TNFSF13B | 2.1E−05 | 1.5E−03 | 3.5 | Tumor necrosis factor superfamily, member 13b |
NLF2 | 2.8E−03 | 3.1E−02 | 3.4 | Nuclear localized factor 2 |
PI16 | 6.1E−09 | 1.7E−05 | 3.3 | Peptidase inhibitor 16 |
MXD4 | 1.1E−07 | 9.8E−05 | 3.3 | MAX dimerization protein 4 |
HPGD | 4.1E−06 | 5.9E−04 | 3.3 | Hydroxyprostaglandin dehydrogenase 15-(NAD) |
SNX29 | 1.9E−05 | 1.4E−03 | 3.2 | Sorting nexin 29 |
TRIB2 | 2.5E−07 | 1.4E−04 | 3.2 | Tribbles homolog 2 |
P2RY5 | 2.3E−07 | 1.3E−04 | 3.1 | Purinergic receptor P2Y, G-protein coupled, 5 |
ZNF381 | 6.4E−06 | 7.3E−04 | 3.0 | Zinc finger protein 831 |
LIME1 | 1.1E−03 | 1.8E−02 | 2.9 | Lck interacting transmembrane adaptor 1 |
MAP3K4 | 4.3E−07 | 1.7E−04 | 2.9 | Mitogen-activated protein kinase kinase kinase 4 |
CD96 | 1.0E−05 | 9.8E−04 | 2.8 | CD96 molecule, transcript variant 1 |
GPR15 | 1.7E−06 | 3.7E−04 | 2.8 | G protein-coupled receptor 15 |
PPARG | 3.2E−06 | 5.1E−04 | 2.7 | Peroxisome proliferator-activated receptor gamma |
GLIPR1 | 6.4E−06 | 7.3E−04 | 2.6 | GLI pathogenesis-related 1 |
CD52 | 3.1E−04 | 3.2E−03 | 2.3 | CD52 molecule |
ARNTL | 3.4E−04 | 8.4E−03 | 2.2 | Aryl hydrocarbon receptor nuclear translocator-like |
FOXO3 | 5.0E−03 | 4.3E−02 | 1.7 | Forkhead box O3 (FOXO3), transcript variant 2, mRNA |