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Fig. 4 | Retrovirology

Fig. 4

From: Lack of a significant impact of Gag-Protease-mediated HIV-1 replication capacity on clinical parameters in treatment-naive Japanese individuals

Fig. 4

The impact of amino acid polymorphisms in Gag on viral fitness. a The x- and y-axes indicate mutation scores and replication capacities, respectively. Mutation scores were calculated by giving −1 for each polymorphism associated with decreased replication capacities in the HLA-B*52:01−B*67:01− subpopulation, i.e. at Gag 79, 228, 286, and 357, and +1 for a polymorphism at Gag 218, which was associated with an increased replication capacity. b Combinations of the Gag-Pro RC-decreasing mutations were generated on pNL4-3, and their effects on viral replication were investigated in vitro

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Retrovirology

ISSN: 1742-4690

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