Table 1 Viral capture of HIV-1 with a panel of monoclonal antibodies measured by p24 or gp120
From: Discrete partitioning of HIV-1 Env forms revealed by viral capture
Antibody | Binding epitope | % p24 | % gp120 | gp120:p24 |
|---|---|---|---|---|
b12 | gp120 CD4bs | 50.9 (1.0) | 75.2 (1.3) | 1.48 |
b6 | gp120 CD4bs | 34.2 (7.9) | 23.8 (3.7) | 0.70 |
1F7 | gp120 CD4bs | 34.9 (1.7) | 52.0 (1.8) | 1.49 |
VRC01 | gp120 CD4bs | 28.6 (4.2) | 78.2 (3.8) | 2.73 |
VRC03 | gp120 CD4bs | 61.0 (1.6) | 85 (12.9) | 1.39 |
17b | gp120 CD4i | 28.3 (7.1) | 35.0 (6.7) | 1.24 |
PG9 | gp120 V2/V3 loop | 69.0 (5.2) | 51.4 (7.9) | 0.74 |
PG16 | gp120 V2/V3 loop | 51.0 (1.2) | 90.5 (14.6) | 1.77 |
2G12 | gp120 mannose | 15.3 (0.6) | 64.0 (3.2) | 4.18 |
4B3 | gp41 cluster I | 60.1 (7.2) | 22.1 (3.2) | 0.37 |
3D6 | gp41 cluster I | 61.8 (2.4) | 18.3 (5.3) | 0.30 |
F240 | gp41 cluster I | 52.7 (8.1) | ND | ND |
7B2 | gp41 cluster I | 39.6 (2.4) | ND | ND |
5F3 | gp41 cluster V | 42.2 (9.4) | ND | ND |
2F5 | gp41 MPER | 47.4 (1.2) | 18.3 (1.3) | 0.39 |
4E10 | gp41 MPER | 32.1 (2.3) | 8.1 (0.5) | 0.25 |
HLA-DR | Host protein | 52.7 (4.6) | 42.0 (7.6) | 0.80 |
CD45 | Host protein | 1.1 (0.1) | 0.1 (0.1) | 0.09 |
IgG isotype | Non-specific | 1.0 (0.0) | 1.1 (0.1) | 1.10 |