Fig. 1

Capture of purified virus by a panel of monoclonal antibodies against Env epitopes and host-derived proteins. Purified HIV-1_BaL virions incubated with a range of antibodies were then retained on magnetic protein G microbeads. The retained, positively bound fraction was expressed as a proportion of the total protein, quantified by either p24 or Env capture ELISA. a Pair-wise representation of the antibody binding to virions when quantified by p24 or gp120 capture. The Wilcoxon matched pairs T Test between p24 and gp120 was insignificant, p = 0.6495. b There was no significant correlation between increased % p24 capture with % gp120 capture. c Combined antibodies in capture assays were quantified by p24 retention, and show an additive effect of combining antibodies targeting multiple Env epitopes. Capture assays were performed in triplicate, and repeated three times. Error bars represent the standard deviation