Fig. 1

Efficacy of TFV gel against SHIV162P3_K65R. a Survival curves representing the cumulative percentage of uninfected macaques as a function of the number of challenges. After 20 SHIV162P3_K65R exposures, challenges were stopped and animals were monitored for ten additional weeks for infection in the follow-up period. b Breakthrough infections show no evidence of blunted viremia. Individual virus load kinetics of controls (black lines) and breakthrough infection (red line) under continued twice-weekly gel dosing. Time zero indicates the time of first SHIV RNA detection in plasma. Time zero indicates the time of first SHIV RNA detection in plasma. The dashed line denotes the limit of quantification of the virus load assay (50 copies/ml).