Fig. 3
From: Human and murine APOBEC3s restrict replication of koala retrovirus by different mechanisms
A potential glyco-gag encoded by KoRV. a Comparison of amino acid sequences in open reading frames upstream of the AUG for Gag polyprotein is shown for different gammaretroviruses. The sequences are shown assuming initiation at a CUG codon (for leucine), giving maximal sequence identity at the N-terminus. M-MuLV Moloney MuLV, KoRV koala retrovirus (J group), GaLV gibbon ape leukemia virus, HERV-H consensus sequence for human endogenous retroviruses of the HERV-H family, FeLV feline leukemia virus. A consensus sequence is shown at the top, with the degree of identity color coded. There is substantial conservation of the N-terminal amino acids (LGDVP) for all viruses except HERV-H and FeLV; HERV-H shares the two first amino acids of this motif (LG). b Amino acid and nucleotide sequences in the region upstream of Pr60gag are shown for KoRV (The Pr60gag AUG is at nt 970). There are three in-frame CUG (CTG) codons; initiation from the CUG at nt 736 would give the sequence shown in (a), with the conserved LGDVP motif. The introduced mutation to generate pKoRV gg- is shown in the b.