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Figure 6 | Retrovirology

Figure 6

From: Impaired Th17 polarization of phenotypically naive CD4+ T-cells during chronic HIV-1 infection and potential restoration with early ART

Figure 6

Effect of early ART initiation on the pool of nTregs, DP, and mTh17 cells. The nTregs, DP, and memory Th17 cells were phenotypically identified as in Figure 2A-B and Figure 4E, respectively. CD4 counts in CI on ART subjects are listed in Table 2. (A) LR and SC models were applied to determine the relationship between the time of ART initiation (months post-infection) versus nTreg counts (left panel), DP counts (middle panel), and Th17 counts (right panel) in CI on ART subjects (n = 11; Table 3, CI #1, 4–7, 9–12, 14–15). (B) LR and SC models were applied to determine the relationship between the nadir CD4 counts versus nTreg counts (left panel), DP counts (middle panel), and Th17 counts (right panel) in CI on ART subjects (n = 16; Table 3, CI #1, 3–12, 14–18). (C) Levels of Gag and integrated HIV-DNA were quantified by real time PCR in total memory CD4+ T-cells sorted by FACS as in Additional file 1: Figure S1 from CI on ART subjects (n = 11). LR and SC models were applied to determine the relationship between the levels of Gag (left panel) and integrated (right panel) HIV-DNA versus the time of ART initiation (months post-infection) in CI on ART subjects (n = 11). LR p and r2 values together with SC p and r values are indicated on the graphs.

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