Figure 5
Expression of Siglec-1 on monocytes correlates with clinical parameters. A. Positive correlation between the mean number of Siglec-1 Ab binding sites per cell and VLP uptake of monocytes isolated from antiretroviral treatment-naïve HIV-1-infected men, with a median of 338 CD4+ T-cell count and 4.3 log10 HIV RNA copies/ml. Graph shows the linear correlation of 26 individuals. Pearson correlation coefficient of the population is denoted by ρ. B. Positive correlation between the mean number of Siglec-1 Ab binding sites per cell and HIV-1 uptake of monocytes isolated from antiretroviral treatment-naïve HIV-1-infected individuals. Graph shows the linear correlation for the 13 individuals from which we recovered enough monocytes to perform this assay. C. Positive correlation between the mean number of Siglec-1 Ab binding sites per cell and the HIV-1 trans-infection capacity of monocytes isolated from antiretroviral treatment-naïve HIV-1-infected individuals. Graph shows the linear correlation for the same individuals as in panel B. D. Positive correlation between the mean number of Siglec-1 Ab binding sites per cell and the plasma viral load at the time of sample analysis of monocytes isolated from antiretroviral treatment-naïve HIV-1-infected individuals. Graph shows a linear correlation for 26 individuals. E. Negative correlation between the mean number of Siglec-1 Ab binding sites per cell and the CD4+ T cell count at the time of sample analysis of monocytes isolated from antiretroviral treatment-naïve HIV-1-infected individuals. Graph shows a linear correlation for 26 individuals.